Professor Michael Seckl
Mechanisms that govern lung cancer biology
(Michael J. Seckl, Ana P. Costa-Pereira, Olivier E. Pardo)
Lung cancer is the commonest cancer killer. Despite patients responding to initial treatment, most relapse with a form of the disease that is chemoresistant. Consequently, novel therapies are urgently required, which will likely arise from a better understanding of disease biology. Our research focuses, therefore, on signal transduction pathways known to be involved in chemoresistance (with particular emphasis on FGF-2) and on the identification of additional mechanisms by which cancer cells can survive, metastasize, and potentially evade the immune system. We have a keen interest on apoptosis, cell migration and cytokine signaling, and utilize a variety of classical and cutting edge molecular biology tools to address these questions.
The clinical specialty relevant to : Oncology, endocrinology, gynaecology and respiratory medicine.
Further information can be obtained using the following links:
http://www1.imperial.ac.uk/medicine/about/divisions/sora/oncology/cancer/oncology/
Contact Details
m.seckl@imperial.ac.uk
Tel: +44 (0)20 8383 8040
a.costa-pereira@imperial.ac.uk
Tel: +44 (0)20 8383 3793
o.pardo@imperial.ac.uk
Tel: +44 (0)20 8383 8040
