Professor Jeremy Nicholson

Biomolecular Medicine

Personalisation of Surgical and Cancer Patient Journeys via Integrative Molecular Phenotyping

We are currently establishing a new translational paradigm for integrative patient phenotyping and modelling that is aimed to optimise a wide range of patient journeys through the hospital system. This involves use of new high end spectroscopic technologies for diagnostic and prognostic disease biomarker discovery and the implementation of this knowledge at point-of-care. In particular we are developing a suite of new tools based on mass spectrometry, NMR spectroscopy and molecular imaging to achieve real-time diagnostic feedback in the surgical environment to enhance clinical decision making and are applying these to a variety of problems including surgical patient monitoring (gut diseases and cancer), critical care (e.g. sepsis and pneumonia), and cancer chemotherapy optimization. These projects are based between the world renowned centre for metabolic phenotyping and top down systems biology in the Section of Biomolecular Medicine and are closely linked to clinical centres at St Mary’s and the Hammersmith Hospital that are all within the Department of Surgery and Cancer.

Clinical specialties this work is relevant to: Surgery, cancer, anaesthetics, obstetrics and gynaecology and public health.

Further Information: http://www1.imperial.ac.uk/surgeryandcancer/divisionofsurgery/biomol_med/research_themes/personalised/

Contact details: j.nicholson@imperial.ac.uk

Tel +44 (0)20 7594 3099