Recent publications

Papadopoulos D, Rundle J, Patel R, Marshall I, Stretton J, Eaton R, Richardson JC, Gonzalez MI, Philpott KL, Reynolds R (2010) FTY720 ameliorates MOG-EAE by suppressing both cellular and humoral immune responses. J Neurosci Res 88:346–359.

Durrenberger PF, Fernando S, Kashefi SN, Ferrer I, J-J Hauw, Seilhean D, Smith C, Walker R, Al-Sarraj S, Troakes C, Palkovits M, Kasztner M, I Huitinga, Arzberger T, Dexter DT, Kretzschmar H and Reynolds R (2010) Effects of antemortem and postmortem variables on human brain mRNA quality: a BrainNetEurope study. J Neuropathol Exp Neurol 69:70-81.

Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2010) Abnormal tau phosphorylation in primary progressive multiple sclerosis. Acta Neuropathol. 119:591–600.

Amadio S, Montilli C, Magliozzi R, Bernardi G, Reynolds R, Volonte C (2010) P2Y12 receptor protein in cortical gray matter lesions in multiple sclerosis. Cerebral Cortex. 20:1263-1273.

Kim JY, Shen S, Dietz K, Seiser C, Howell O, Reynolds R, He Y, Casaccia-Bonnefil P (2010) Nuclear export of HDAC1 is induced by pathological conditions and is essential for the onset of axonal damage. Nature Neurosci. 13:180-189.

AndrodiasG, Reynolds R, ChanalM, Ritleng C, Confavreux C, Nataf S (2010) A link between meningeal T-cells and axonal loss in progressive multiple sclerosis spinal cords. Ann Neurol. 68:465-476.

Owen DR, Howell OW, Tang SP, Wells LA, Bennacef I, Bergstrom M, Gunn RN, Rabiner EA, Wilkins MR, Reynolds R, Matthews PM, Parker CA (2010) Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation. Journal of Cerebral Blood Flow & Metabolism. 30:1608-1618.

Serafini B, Severa M, Columba-Cabezas S, Rosicarelli B, Veroni C, Chiappetta G, Magliozzi R, Reynolds R, Coccia EM, Aloisi F (2010) Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation. J Neuropath Exp Neurol. 69:677-693.

Howell OW, Rundle JL, Garg A, Komada M, Brophy PJ, Reynolds R (2010) Activated microglia mediate axo-glial disruption that contributes to axonal injury in multiple sclerosis. J Neuropath Exp Neurol. 69:1017-1033.

Aloisi F, Serafini B, Magliozzi R, Howell O, Reynolds R (2010) Detection of Epstein-Barr virus and B-cell follicles in the multiple sclerosis brain:  what you find depends on how and where you look. Brain epub Aug 25.

Magliozzi R, Howell OW, Reeves C, Roncaroli F, Nicholas R, Serafini B, Aloisi F and Reynolds R (2010) A gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Ann Neurol. 68:477-493.

Owen DR, Gunn RN, Rabiner EA, Bennacef I, Fujita M, Kreisl WC, Innis RB, Pike VW, Reynolds R, Matthews PM, Parker CA (2010) Mixed affinity binding in humans with 18 kDa translocator protein (TSPO) ligands. J Nuc Med. 52:24-32.

Campbell GR, Ziabreva I, Reeve AK, Krishnan KJ, Reynolds R, Howell O, Lassmann H, Turnbull DM, Mahad DJ (2011) Mitochondrial deletions within neurons in multiple sclerosis. Ann Neurol 69:481-492.

Sun G, Reynolds R, Leclerc I, Rutter G (2011) LKB1 deletion causes axon degeneration in the spinal cord and hid-limb paralysis. Disease Models & Mechanisms 4:193-202.

Schmitt A, Leonardi-Essmann F, Durrenberger PF, Parlapani E, Spanagel R, Herrera-Marschitz M, Reynolds R, Falkai P, Gebicke-Haeter PJ. (2011) Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients. World J Biol Psych 12:201-215.

Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger S, Howell O, Reynolds R, O’Connor KC, Hafler DA (2011) A network of B-cells populates the meninges and parenchyma of patients with MS. Brain 134:534-541.

Owen DRJ, Lewis AJM, Reynolds R, Rupprecht R, Eser D, Wilkins MR, Nutt DJ, Parker CA (2011) Variation in binding affinity of the novel anxiolytic XBD172 for the 18kDa translocator protein in human brain. Synapse. 65:257-259.

Reynolds R, Roncaroli F, Nicholas R, Radotra B, Gveric D, Howell O (2011) The neuropathological basis of clinical progression in multiple sclerosis. Acta Neuropathol 122:155-170.

Howell OW, Reeves CA, Carassiti D, Nicholas R, Radotra B, Gentleman S, Roncaroli F, Gveric D, Serafini B, Aloisi A, Magliozzi R, Reynolds R (2011) Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain 134:2755-2771.

The International Multiple Sclerosis Genetics Consortium (IMSGC) (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476:214-219.

Politis M, Giannetti P, Su P, Turkheimer F, Keihaninejad S, Wu K, Waldman A, Reynolds R, Nicholas R, Piccini P (2012) Microglial activation in the cortical grey matter of patients with multiple sclerosis correlates with measures of impairment. In press in Neurology.

Durrenberger PF, Grünblatt E, Fernando FS, Monoranu CM, Evans J, Riederer P, Reynolds R, Dexter DT (2012) Inflammatory pathways in Parkinson’s disease – a BNE microarray study. In press in Parkinson’s Disease. 

Durrenberger PF, Ettorre A, Kamel F, Webb LV, Sim M, Nicholas RS, Malik O, Reynolds R, Boyton RJ, Altmann DM (2012) Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1). J Neuroinflammation on line.

McMahon JM, McQuaid S, Reynolds R, Fitzgerald U (2012) Expression of ER stress and hypoxia associated molecules in grey matter lesions in multiple sclerosis. Multiple Sclerosis J , early access.