Gene regulation in bacterial pathogens

My laboratory primarily investigates the mechanisms by which the bacterial RNA polymerase (RNAP) operates. The RNAP is frequently the target of sophisticated signal transduction pathways that serve to link environmental, metabolic and developmental cues to the regulation of gene expression at the transcriptional level. Our research seeks to understand the molecular mechanisms that govern virulence gene expression in bacterial pathogens at the transcriptional level and at the level of RNAP activity.

For more information on the work of this group, please refer to Dr Wigneshweraraj's page on the Centre for Molecular Microbiology and Infection website.