Professor Malcolm G Parker

Professor of Molecular Endocrinology

Research Interests

• Nuclear receptor signalling in cancer, metabolism and reproduction.
• Role of transcriptional cofactors in gene expression.

Membership of Societies

• EMBO member
• Fellow of Academy of Medical Sciences
• Biochemical Society
• Endocrine Society (USA)
• Society for Endocrinology (UK)

Key publications

Nautiyal J, Steel JH, Mane MR, Oduwole O, Poliandri A, Alexi, Wood N, Poutanen M, Zwart W, Stingl J and Parker MG [2013] The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development. 2013 Mar;140(5):1079-89.

Percharde M, Lavial F, Ng JH, Kumar V, Tomaz RA, Martin N, Yeo JC, Gil J, Prabhakar S, Ng HH, Parker MG and Azuara V [2012] Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev. 2012 Oct 15;26(20):2286-98.

Nautiyal J, Steel JH, Rosell MM, Nikolopoulou E, Lee K, Demayo FJ, White R, Richards JS, Parker MG. [2010] The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphirregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary. Endocrinology 151(6):2923-32

Morganstein DL, Wu P, Mane MR, Fisk NM, White R and Parker MG. [2010] Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression. Cell Res. Apr;20 (4): 434-44

Seth A, Steel JH, Nichol D, Pocock V, Kumaran MK, Fritah A, Mobberley M, Ryder TA, Rowlerson A, Scott J, Poutanen M, White R and Parker M.  [2007]  The Transcriptional Corepressor RIP140 Regulates Oxidative Metabolism in Skeletal Muscle. Cell Metab. Sep;6(3):236-45

Kiskinis E, Hallberg M, Christian M, Olofsson M, Dilworth SM., White R and Parker MG. [2007] RIP140 directs histone modifications and de novo DNA methylation activity to silence Ucp1 gene expression in white adipocytes.  EMBO J 26, 4831-40

White R, Leonardsson G, Roswell I, Jacobs MA, Milligan S and Parker M. [2000] The nuclear receptor co-repressor Nrip1 (RIP140) is essential for female fertility. Nat Med. Dec;6(12):1368-74

Heery DM, Kalkhoven E, Hoare S and Parker MG. [1997] A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387, 733-736

Cavailles V, Dauvois S, L’Horset F, Lopez G, Hoare S, Kushner PJ, and Parker MG. [1995] Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J .14, 3741-3751