Contact details
Professor Jeremy K Nicholson
Chair In Biological Chemistry, Head of Department
Department of Surgery & Cancer
Tel: +44 (0)20 7594 3195
Email:
Professor Jeremy K Nicholson
Research Interests:.
- Molecular physio-chemical processes in metabolism and medicine.
- Development of novel spectroscopic and chemometric tools for investigating human disease and toxicological mechanisms.
- Metabolism-driven top-down systems biology and modelling of complex system failure.
- Personalised healthcare through metabolic phenotyping.
- Surgical metabonomics, real-time diagnostics and integrative patient modelling.
Membership of societies
Fellow of the Academy of Medical Sciences
Fellow of the Institute of Biology
Fellow of the Royal College of Pathologists
Fellow of the Royal Society of Chemistry
Fellow of the British Toxicological Society
Selected Honours and Awards etc.:
Honorary Professor of Systems Biology, Shanghai Jiao Tong University;
Honorary Professor of Analytical Chemistry, Chinese Academy of Sciences, Dalian, China;
Honorary Professor of Chemistry, Tsinghua University, Beijing, China;
Honorary Professor of Medicine, Zhe Jaing University, Hongzhou, China;
Honorary Professor of Systems Biology Shanghai TCM University, China;
Honorary Professor of Biological Spectroscopy, State Key Laboratory of Magnetic Resonance and Molecular & Atomic Physics, Chinese Academy of Sciences, Wuhan, China;
Honorary Director of the Metabonomics Research Centre, Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China;
Honorary Director of Wuhan Magnetic Resonance Research Centre, Chinese Academy of Sciences, Dalian, China.
The Royal Society of Chemistry: 21st Silver Medal for Analytical Science (1992)
The Chromatographic Society: Jubilee Silver Medal (1994)
The Royal Society of Chemistry: 21st SAC Gold Medal for Analytical Chemistry (1997)
Pfizer Academic Innovation Award for Chemical and Medicinal Technology (2002)
The Royal Society of Chemistry: Silver Medal for Chemical Biology (2003)
Pfizer Global Chemistry Disciplinary Prize (2006)
The Royal Society of Chemistry (2007) - Theophilus Redwood Lecturer
The Royal Society of Chemistry (2008) – Interdisciplinary award
NIH: Stars in Cancer and Nutrition Distinguished Lecturer (2010)
Semmelweis – Budapest Prize (2010)
External Scientific Duties:
Consulting Editor: Journal of Proteome Research (ACS)
Associate Editor: Biomarkers (Taylor Francis Press)
Editorial Board: Molecular Systems Biology
Spin off company
Non-Executive (Founder) Director, Metabometrix UK Ltd.
Selected Publications
Journals
- Swann JR; Want EJ; Geier FM; Spagou K; Wilson ID; Sidaway JE; Nicholson JK; Holmes E. (15 Mar 2011). Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci U S A. 108 Suppl 1:4523-4530. DOI.
- Heinzmann SS; Brown IJ; Chan Q; Bictash M; Dumas ME; Kochhar S; Stamler J; Holmes E; et alElliott P; Nicholson JK. (Aug 2010). Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption. Am J Clin Nutr. 92:436-443. DOI.
- Clayton TA; Baker D; Lindon JC; Everett JR; Nicholson JK. (25 Aug 2009). Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:14728-14733. Author weblink DOI.
- Nicholson JK; Lindon JC. (23 Oct 2008). Systems biology - Metabonomics. NATURE. 455:1054-1056. Author weblink DOI.
- Holmes E; Loo RL; Stamler J; Bictash M; Yap IK; Chan Q; Ebbels T; De Iorio M; et alBrown IJ; Veselkov KA; Daviglus ML; Kesteloot H; Ueshima H; Zhao L; Nicholson JK; Elliott P. (15 May 2008). Human metabolic phenotype diversity and its association with diet and blood pressure. Nature. 453:396-400. DOI.
- Li M; Wang B; Zhang M; Rantalainen M; Wang S; Zhou H; Zhang Y; Shen J; et alPang X; Zhang M; Wei H; Chen Y; Lu H; Zuo J; Su M; Qiu Y; Jia W; Xiao C; Smith LM; Yang S; Holmes E; Tang H; Zhao G; Nicholson JK; Li L; Zhao L. (12 Feb 2008). Symbiotic gut microbes modulate human metabolic phenotypes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 105:2117-2122. Author weblink DOI.
- Martin F-PJ; Wang Y; Sprenger N; Yap IKS; Rezzi S; Ramadan Z; Pere-Trepat E; Rochat F; et alCherbut C; van Bladeren P; Fay LB; Kochhar S; Lindon JC; Holmes E; Nicholson JK. (1 Jul 2008). Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. MOLECULAR SYSTEMS BIOLOGY. 4. Author weblink DOI.
- Martin F-PJ; Wang Y; Sprenger N; Yap IKS; Lundstedt T; Lek P; Rezzi S; Ramadan Z; et alvan Bladeren P; Fay LB; Kochhar S; Lindon JC; Holmes E; Nicholson JK. (1 Jan 2008). Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. MOLECULAR SYSTEMS BIOLOGY. 4. Author weblink DOI.
- Claus SP; Tsang TM; Wang Y; Cloarec O; Skordi E; Martin FP; Rezzi S; Ross A; et alKochhar S; Holmes E; Nicholson JK. (Oct 2008). Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Molecular Systems Biology. 4.
- Clayton TA; Lindon JC; Cloarec O; Antti H; Charuel C; Hanton G; Provost JP; Le Net JL; et alBaker D; Walley RJ; Everett JR; Nicholson JK. (20 Apr 2006). Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature. 440:1073-1077. DOI.
- Nicholson JK; Holmes E; Wilson ID. (May 2005). Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol. 3:431-438. DOI.
- Nicholson JK; Connelly J; Lindon JC; Holmes E. (Feb 2002). Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov. 1:153-161. DOI.
