Dr Jaya Nautiyal

Research Interests

Physiological processes in the body are regulated by pathways activated by hormones and  growth factors. Receptor interacting protein-140 (RIP140) is a transcriptional coregulator of several nuclear receptors and transcription factors and consequently  affects metabolism, inflammation and female fertility. Mice devoid of RIP140 fail to ovulate and are thus infertile.

Amphiregulin   is  a growth factor belonging to the epidermal growth factor family which plays  roles in ovulation and in mediating the effects of estrogen in mammary gland development. In the ovary amphiregulin  is  expressed in the preovulatory follicle as an immediate response to the Luteinizing hormone (LH) surge to bring about cumulus expansion followed by ovulation. We have found RIP140 activates the transcription of amphiregulin  with, b zip transcription factors CREB and c Jun in the ovary.  The aim of my project is to further understand the pathways regulated by RIP140 which impact hormone and growth factor action.