Dr Daqing Ma
Surgery and Cognitive Decline
My research group is currently pursuing three areas of research. Firstly, we are exploring the molecular basis for the link between surgery and cognitive decline, and will evaluate potential treatments to prevent these changes. Secondly, we are examining the protective effects of anaesthetics – for example, how they may be employed to reduce the risk of organ damage due to ischemia. Finally, we are investigating the influence of anaesthesia on cancer recurrence after surgery.
Grant Awarded (selected, >30K):
- BJA/RCoA, Project grant, 2007–2009, £53K, PI.
- AAGBI, Project grant 2008–2009, £43K, PI.
- European Society of Anaesthesiology, Project grant 2009–2011, £47K, PI.
- Action Medical Research, Project grant 2009-2011. £49K, PI.
- MRC, DPFS 2009-2011, £450K PI.
- Alzheimer’s Society-Bupa foundation , Project grant, 2011-2013, £140K, PI
Bibliography (selected):
- Ma D, Hossain M, Chow A, Arshad M, Battson R, Sanders RD, Mehmet M, Edwards D, Franks NP, Maze M. Xenon and hypothermia combine synergistically to provide potent and long-lasting neuroprotection from neonatal asphyxia by attenuating apoptotic cell death. Annals of Neurology 2005;58:182-93.
- Ma D, Hossain M, Pettet GKJ, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M. Xenon Preconditioning Reduces Brain Damage from Neonatal Asphyxia in Rats. Journal of Cerebral Blood Flow & Metabolism 2006;26;199-208.
- Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Franks NP, Maze M. Xenon mitigates isoflurane-induced apoptotic neurodegeneration in the developing rodent brain. Anesthesiology 2007;106:746-53.
- Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M. Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1α activation. Journal of American Society of Nephrology 2009;20:713-20.
- Limatola V, Ward P, Cattano D, Gu J, Giunta F, Maze M, Ma D. Xenon Preconditioning Confers Neuroprotection Regardless of Gender in A Mouse Model of Transient Middle Cerebral Artery Occlusion. Neuroscience 2010;165:874-81.
- Rizvi M, Jawad N, Li Y, Vizcaychipi PM, Maze M, Ma D. The effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Journal of Experimental Biology and Medicine 2010; 235:886–891.
- Wan Y, Xu J, Meng FM, Bao YH, Ge YY, Lobo N, Vizcaychipi MP, Zhang DH, Gentleman SM, Maze M, Ma D. Cognitive decline following major surgery is associated with Alzheimer’s Disease pathogenesis in old mice. Crit Care Med. 2010;38:2190-2198.
- Shu Y, Patel SM, Pac-Soo C, Fidalgo AR, Wan Y, Maze M, Ma D. Xenon pre-treatment attenuates anesthetics-induced apoptosis in the developing brain: in comparison with nitrous oxide and hypoxia. Anesthesiology 2010;113:360-8.
- Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M. Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol. 2010;68:360-8.
- Terrando N, Monaco C, Ma D, Foxwell BMJ, Feldmann M, Maze M. Tumor necrosis factor-α (TNF-α) triggers a cytokine cascade yielding postoperative cognitive decline. PNAS (in press).
Contact details:
Tel: +44 (0)20 3315 8495
Email: d.ma@imperial.ac.uk
