Sample projects

The table lists some of the projects that have been undertaken by our students:

• The effect of Prazosin, an alpha1-adrenoceptor antagonist, on APP processing and amyloid deposition, in vitro and in vivo.
• Molecular targets of an anti-inflammatory drug in chronic pain.
• A study of the treatment of essential tremor: report on 200 patients
• Study to characterise the nature of the innate immune response in the Parkinsonian brain.
• Investigating the impact of Cdk5 activity in EAE and MS.
• Epigenetic silencing of genes in glial brain tumours
• The pathoanatomical basis for visual hallucinations in Parkinson’s disease.
• Assessing the role of the visual cortex in attentional guidance by the contents of working memory: a tDCS study
• The neural correlates of vestibular spatial working memory
• The effect of polyunsaturated fatty acid derivatives as potential Alzheimer’s disease therapy.
• Task based modulation for number and word processing in the ventral visual stream.
• Microglia, amyloid and glucose metabolism in mild cognitive impairment and Alzheimer’s disease: an [11](R)PK11195-PET, [11C]PIB-PET and [18F]FDG-PET
• Cloning and production of a lentiviral vector encoding sequences that mediate chaperone-mediated autophagy and neuroprotection  in models of huntington’s disease
• Effects of Annexin A1 on paracellular permeability of the microvascular endothelium of the blood-brain-barrier.
• D-serine synthesis and metabolism in Alzheimer’s disease brain.